Horiba Yumizen D20 Digital Cell Morphology

Yumizen D20

Digital Cell Morphology System

An in-vitro diagnostic device designed to automate manual microscopy in a diagnostic laboratory. It uses robotics and AI to digitize Blood and Urine samples to enable AI aided remote review. It generates a pre-classified report of blood and urine with accuracy. This report can be accessed and approved from anywhere, ensuring timely and accurate results to meet patient's needs.

The Yumizen D20 has 2 modules.

1. Shonit: An AI application to analyze blood cell morphology which identifies and pre-classifies WBCs, RBCs and platelets in a peripheral blood smear.
2. Shrava: An AI application to analyze urine sediment to identify and pre-classify multiple elements present in urine sediment.

Segment:

Healthcare

Division:

Hematology

Base product:

Peri Analytical

• One device, multiple tests - The device can digitize and analyze both blood and urine.
• Value-added reports - A standardized report for peripheral smear and urine sediment analysis with visual images of the cells/particles in the final report.
• Review reports from anywhere and anytime. The web-enabled reports allow pathologists to work from anywhere.
• AI-assisted analysis- Automated WBC DC, RBC morphology, and platelet morphology reporting with visual evidence.
• The Microscopic view enables the pathologist to virtually “see” the slide as if it were under a microscope.
• Stain – The analyzer is compatible with all Romanowsky stains.
• Smear - Shonit is compatible with both manual and automated smears.
• Sample Preparation Quality Check - The system provides feedback on the quality of slides for each sample analyzed.
• High Throughput – Yumizen D20 can scan 20 slides per hour for blood analysis. It can scan 40 samples per hour for urinalysis, where it takes 25 FOV (Fields of view).
• Simplified Sample Preparation - A single-use, leakproof, drift arresting urine cartridge, GS200μ, simplifies the urine sample preparation.
• Remote Collaboration - Collaborate with colleagues on special cases without being hindered by geographical separation.
• Unlimited Cloud Storage - No more worrying about storage running out. We take care of all your data. Forever!
• Hassle-free Upgrades - Remote upgrades for better performance and new products.

Shonit module

Shrava module

Analyzer type

Blood morphology analyzer

Urine sediment analyzer

Parameters

WBC –LYM%, MON%, NEU%, EOS%, BAS%, IG%, Atypical/Blasts%, NRBC%, Immature cells

RBC anisocytosis-
Normocyte*, Microcyte*, Round Macrocyte*,Ovalo Macrocyte*

RBC Poikilocytosis –
Elliptocyte*, Ovalocyte*, Target*, Teardrop*, Echinocyte*, Fragmented*

Platelets-
PLT, Macro PLT, Giant PLT, Platelet Clumps
*IHS Grades

Semi-Quantitative:
RBC, PUS cells, Microorganisms

Detected vs Not Detected: Epithelial Cells, Cast, Crystal, Yeast

Sample preparation

Manual or automated peripheral blood smears on glass slides with a thin layer of oil

Specially designed single-use cartridge GS200µ charged with 100µl of a uncentrifuged urine sample

Throughput

20 slides per hour

40 samples per hour

Slide/Cartridge loading

Single slide at a time

Single cartridge at a time

Slide/Cartridge specifications

Length – 74 to 76 mm
Width – 24 to 26 mm
Thickness – 1.0 to 1.35 mm

GS200µ cartridges

Oil immersion

A thin layer of oil to be applied manually

Stains

Romanowsky Stains (Leishman,May-GrÜnwald- Giemsa, Wright Giemsa, Giemsa)

Regulatory approval

CE IVDR

Camera

• CMOS Sensor
• 14 Megapixel Resolution

Optics system

• Single optical column
• 40X Objective lens
• Optical resolution of approximately 700 lp/mm
• Digital resolution of approximately 6.1 pixels/micron

Illumination source

White LED

Stage movement resolution

• XY axis – 0.25 µm
• Z axis – 0.06 µm

Stage travel speed

• XY axis – 12 mm/sec
• Z axis – 3 mm/sec

Barcode reader

External barcode reader

Quality control

• Performance qualification test for hardware and image quality
• Built-in assessment test of sample preparation quality

Archiving of results and images

Unlimited archiving in Mandara utilizing either LAN or Wi-Fi

External interface

• USB
• Ethernet

Electrical specifications

• Input Voltage: 100-240VAC
• Nominal Power: 60 Watt
• AC frequency: 50/60 Hz

Size (W x D x H)

485mm x 572mm x 485mm / 19.1in x 22.52in x 19.1in

Weight

49 Kg / 108 lbs