Factor Deficient Plasmas

HORIBA offers a complete range of immunodepleted Factor Deficient Plasmas covers both the extrinsic and intrinsic coagulation cascade pathways. These lyophilized human plasmas contain less than 1% residual factor activity while maintaining normal levels of other coagulation factors. Deficient plasmas used for quantitative determination of factor II, V, VII, X with prothrombin time (PT) thromboplastin time reagent and one-stage coagulation test in decalcified plasmas. The decreased level of factors in common and extrinsic pathway could be observed in the following cases: • Congenital or acquired factor deficiency states • During treatment with anticoagulants • In case of vitamin K deficiency (reduced intake or metabolic disorder) • Liver disease (cirrhosis, hepatitis) • During factor “depletion” due to disseminated intravascular coagulopathy (DIC). Deficient plasmas used for quantitative determination of factor VIII, IX, XI, XII with activated partial thromboplastin time (APTT) reagent and one-stage coagulation test in decalcified plasmas. The decreased level of factors in common and intrinsic pathway could be observed in the following cases: • Congenital or acquired factor deficiency states (Hemophilia A: factor VIII deficiency, Hemophilia B: factor IX deficiency) • Liver disease • Autoimmune hemophilia states